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HISTONE DEACETYLASES
Descriptors Found:
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DeCS
Descriptor
English
:
Histone Deacetylases
Descriptor
Spanish
:
Histona Desacetilasas
Descriptor
Portuguese
:
Histona Desacetilases
Tree Number:
D08.811.277.087.520
Definition
English
:
Deacetylases that remove N-acetyl groups from amino side chains of the
amino acids
of
HISTONES
. The enzyme
family
can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin
histone deacetylases
belong to class III and are NAD-dependent
enzymes.
Entry Combination - descr/qualif
English
:
Histone Deacetylases
/
antagonists & inhibitors
use
Histone Deacetylase Inhibitors
History Note
English
:
2003; use AMIDOHYDROLASES 1975-1990
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
6816
Unique Identifier:
D006655
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS